Vito Foderà
Vito is a biophysicist with extensive experience in method development for the study of biological reactions.
Vito is leading a group at the University of Copenhagen working on protein-protein interactions and their implications in fields such as protein drug development, neurodegenerative diseases and protein-based materials for drug delivery.
Combining different experimental approaches, from spectroscopy and advanced imaging to synchrotron-based techniques, with theoretical models is a fingerprint of Vito’s research.
Favourite Applications
Liquid-Liquid Phase Separation
Take full control of your condensates. Labbot can help you fine-tune solution conditions and map out phase behavior in unrivaled detail, giving you a better understanding of how droplets come and go.
Amyloid Aggregation
Maximize the information obtained from each sample and untangle the complexities of fibril growth. By combining full spectrum readouts with light scattering and exercising complete control over sample conditions, you can easily set up your next amyloid experiment.
Protein Interactions
Take classical methods to new heights with automated measurements. Detect ligand binding or oligomerization with FRET or by tracking changes in intrinsic fluorescence.
Our research has different branches, ranging from physics of biological systems to drug delivery. I invested in Labbot since I was looking for a versatile system to be used to monitor protein phase transition and for the detailed analysis of release kinetics from several drug delivery systems.
The automatic titration system combined with the ability to simultaneously monitor/measure/record pH represents a big advantage when a systematic screening of physico-chemical conditions needs to be performed, both in the case of protein phase separation and drug release experiments.
Moreover, the simultaneous detection of fluorescence and scattering allows coupling information on the macroscopic properties of the solution with details on the conformational state of the protein. This overall setup has dramatically reduced the duration of our experiments, guaranteeing access to a large amount of data in a relatively short amount of time.