Applications

What can you investigate with Labbot?

The list of featured applications is long and ever growing.
Here are some of the most used ones.
Application

Liquid-Liquid Phase Separation

Take full control of your condensates. Labbot can help you fine-tune solution conditions and map out phase behavior in unrivaled detail, giving you a better understanding of how droplets come and go.

Application

Protein Interactions

Take classical methods to new heights with automated measurements. Detect ligand binding or oligomerization with FRET or by tracking changes in intrinsic fluorescence.

Application

Amyloid Aggregation

Maximize the information obtained from each sample and untangle the complexities of fibril growth. By combining full spectrum readouts with light scattering and exercising complete control over sample conditions, you can easily set up your next amyloid experiment.

Application

Thermal Stability

Follow protein unfolding with intrinsic fluorescence or external probes while Labbot scans temperature across your defined range. Easily track any resulting aggregation with static light scattering for a full thermal profile of your protein.

Application

Metal Ion Binding

Labbot's automated titration provides detailed binding curves for a deeper understanding of protein-metal ion interactions. You can obtain your measurement output via absorbance or fluorescence spectroscopy, depending on your assay's needs.

Application

pH Stability

Labbot collects real-time data from an attached pH meter for highly detailed pH titrations, including measuring the isoelectric point of a protein, mapping pH-dependent phase behaviors, or monitoring other pH-affected processes.

Application Notes

Guides for your next experiment

Together with the Labbot community we write application notes for the different experiments Labbot can help with. Looking for a specific app note? Let us know!
Liquid-Liquid Phase Separation

LLPS (Temperature)

Map out the determinants of phase separation.
Alexander K. Buell
December 1, 2023
Liquid-Liquid Phase Separation

LLPS (Salt)

Map out the determinants of phase separation.
Alexander K. Buell
March 22, 2023
Other

Automatic Correction of Inner Filter Effect

Labbot simplifies IFE correction since you can measure the full-spectrum absorbance of the sample at every point of measurement, allowing for continuous, automatic correction.
Mattias Törnquist
December 20, 2023
Protein Interactions

FRET

Track interactions using FRET.
Sara Snogerup Linse
December 1, 2023